Interactive Toxicogenomics: Gene set discovery, clustering and analysis in Toxygates.

ABSTRACT: Toxygates was originally released as a user-friendly interface to enhance the accessibility of the large-scale toxicogenomics database, Open TG-GATEs, generated by the Japanese Toxicogenomics Project. Since the original release, significant new functionality has been added to enable users to perform sophisticated computational analysis with only modest bioinformatics skills. The new features include an orthologous mode for data comparison among different species, interactive clustering and heatmap visualisation, enrichment analysis of gene sets, and user data uploading. In a case study, we use these new functions to study the hepatotoxicity of peroxisome proliferator-activated receptor alpha (PPARα) agonist WY-14643. Our findings suggest that WY-14643 caused hypertrophy in the bile duct by

SUBMITTER: Nystrom-Persson J 

PROVIDER: S-EPMC5431224 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature