DNA methylation and Transcriptome Changes Associated with Cisplatin Resistance in Ovarian Cancer.

ABSTRACT: High-grade serous ovarian cancer is the most common ovarian cancer type. Although the combination of surgery and platinum-taxane chemotherapy provide an effective treatment, drug resistance frequently occurs leading to poor outcome. In order to clarify the molecular mechanisms of drug resistance, the DNA methylation and transcriptomic changes, associated with the development of drug resistance in high-grade serous ovarian cancer, were examined from patient derived malignant ascites cells. In parallel with large-scale transcriptome changes, cisplatin resistance was associated with loss of hypermethylation at several CpG sites primarily localized in the intergenic regions of the genome. The transcriptome and CpG methylome changes in response to cisplatin treatment of both sensitive and resis

SUBMITTER: Lund RJ 

PROVIDER: S-EPMC5431431 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature