Aggressiveness of the tall cell variant of papillary thyroid carcinoma is independent of the tumor size and patient age.

ABSTRACT: The tall cell variant (TCV) of papillary thyroid carcinoma (PTC) is characterized by tall columnar cells with a height of at least three times their width. TCV usually presents at an older age, has a larger size and exhibits more extrathyroidal extension and metastases than classical PTC. The current study compared TCV with the classical and follicular variants (CaFVs) of PTC to determine if, irrespective of the age at diagnosis and tumor size, TCV is more aggressive than its classical and follicular counterparts. A total of 16 (3.66%) patients with TCV were identified in a series of 437 patients with PTC from the Clinical University Hospital (Santiago de Compostela, Spain) between 1990 and 2010. The patient clinicopathological features and B-Raf proto-oncogene (BRAF)V600E mutational statu

SUBMITTER: Villar-Taibo R 

PROVIDER: S-EPMC5431510 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature