Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger.

ABSTRACT: Brain insulin sensitivity is an important link between metabolism and cognitive dysfunction. Intranasal insulin is a promising tool to investigate central insulin action in humans. We evaluated the acute effects of 160 U intranasal insulin on resting-state brain functional connectivity in healthy young adults. Twenty-five lean and twenty-two overweight and obese participants underwent functional magnetic resonance imaging, on two separate days, before and after intranasal insulin or placebo application. Insulin compared to placebo administration resulted in increased functional connectivity between the prefrontal regions of the default-mode network and the hippocampus as well as the hypothalamus. The change in hippocampal functional connectivity significantly correlated with visceral adipo

SUBMITTER: Kullmann S 

PROVIDER: S-EPMC5431641 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature