Angiotensin II type 1/adenosine A _2A receptor oligomers: a novel target for tardive dyskinesia.

ABSTRACT: Tardive dyskinesia (TD) is a serious motor side effect that may appear after long-term treatment with neuroleptics and mostly mediated by dopamine D₂ receptors (D₂Rs). Striatal D₂R functioning may be finely regulated by either adenosine A_2A receptor (A_2AR) or angiotensin receptor type 1 (AT₁R) through putative receptor heteromers. Here, we examined whether A_2AR and AT₁R may oligomerize in the striatum to synergistically modulate dopaminergic transmission. First, by using bioluminescence resonance energy transfer, we demonstrated a physical AT₁R-A_2AR interaction in cultured cells. Interestingly, by protein-protein docking and molecular dynamics simulations, we described that a stabl

SUBMITTER: Oliveira PA 

PROVIDER: S-EPMC5431979 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature