Common Variants in OPG Confer Risk to Bone Mineral Density Variation and Osteoporosis Fractures.

ABSTRACT: Although many common variants have been identified for bone mineral density (BMD) and osteoporosis fractures, all the identified risk variants could only explain a small portion of heritability of BMD and osteoporosis fractures. OPG belongs to the tumor necrosis factor receptor superfamily, which plays a crucial role in bone remodeling and is thus a promising candidate gene of osteoporosis. Several studies have explored the association of OPG variants with BMD or osteoporosis fractures, however, the results remain inconsistent among different populations. In the study, we first assessed the relationship between OPG variants and BMD or osteoporosis fractures in our sample size (227 subjects with postmenopausal osteoporosis and 189 controls), and then performed a systematic meta-analysis. Am

SUBMITTER: Sheng X 

PROVIDER: S-EPMC5432005 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature