The clinico-radiological paradox of cognitive function and MRI burden of white matter lesions in people with multiple sclerosis: A systematic review and meta-analysis.

ABSTRACT:

Background

Moderate correlation exists between the imaging quantification of brain white matter lesions and cognitive performance in people with multiple sclerosis (MS). This may reflect the greater importance of other features, including subvisible pathology, or methodological limitations of the primary literature.

Objectives

To summarise the cognitive clinico-radiological paradox and explore the potential methodological factors that could influence the assessment of this relationship.

Methods

Systematic review and meta-analysis of primary research relating cognitive function to white matter lesion burden.

Results

Fifty papers met eligibility criteria for review, and meta-analysis of overall results was possible in thirty-two (2050 participants). Aggregate cor

SUBMITTER: Mollison D 

PROVIDER: S-EPMC5432109 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature