A Phase Separation Model for Transcriptional Control.

ABSTRACT: Phase-separated multi-molecular assemblies provide a general regulatory mechanism to compartmentalize biochemical reactions within cells. We propose that a phase separation model explains established and recently described features of transcriptional control. These features include the formation of super-enhancers, the sensitivity of super-enhancers to perturbation, the transcriptional bursting patterns of enhancers, and the ability of an enhancer to produce simultaneous activation at multiple genes. This model provides a conceptual framework to further explore principles of gene control in mammals.

SUBMITTER: Hnisz D 

PROVIDER: S-EPMC5432200 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature