Ontology highlight
ABSTRACT:
SUBMITTER: Chang J
PROVIDER: S-EPMC5432238 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Oncotarget 20170401 16
Lysyl Oxidase-like 2 (LOXL2), a member of the lysyl oxidase family of amine oxidases is known to be important in normal tissue development and homeostasis, as well as the onset and progression of solid tumors. Here we tested the anti-tumor properties of two generations of novel small molecule LOXL2 inhibitor in the MDA-MB-231 human model of breast cancer. We confirmed a functional role for LOXL2 activity in the progression of primary breast cancer. Inhibition of LOXL2 activity inhibited the grow ...[more]