Glycated haemoglobin (HbA_1c ) and fasting plasma glucose relationships in sea-level and high-altitude settings.

ABSTRACT:

Aim

Higher haemoglobin levels and differences in glucose metabolism have been reported among high-altitude residents, which may influence the diagnostic performance of HbA_1c . This study explores the relationship between HbA_1c and fasting plasma glucose (FPG) in populations living at sea level and at an altitude of > 3000 m.

Methods

Data from 3613 Peruvian adults without a known diagnosis of diabetes from sea-level and high-altitude settings were evaluated. Linear, quadratic and cubic regression models were performed adjusting for potential confounders. Receiver operating characteristic (ROC) curves were constructed and concordance between HbA_1c and FPG was assessed using a Kappa index.

Results

At sea level and high altitude, means wer

SUBMITTER: Bazo-Alvarez JC 

PROVIDER: S-EPMC5432378 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature