Association of sFlt-1 and worsening psychopathology in relatives at high risk for psychosis: A longitudinal study.

ABSTRACT:

Background

Angiogenic dysfunction and abnormalities in psychopathology and brain structure have been reported in schizophrenia, but their relationships are mostly unknown. We recently demonstrated that sFlt-1, anti-angiogenic factor, was significantly elevated in patients at familial high-risk for psychosis (FHR). We hypothesized that elevated sFlt-1 correlates with baseline and longitudinal changes in psychopathology, cognition, and brain structure.

Methods

Plasma sFlt-1 in FHR (n=35) and HC (n=39) was obtained at baseline. Schizotypal, cognitive, soft neurologic signs, and structural brain imaging (1.5T T1-weighted MRI, FreeSurfer software) measures were obtained in both groups. Longitudinal clinical and brain structural measures were obtained in a subgroup of FHR patients

SUBMITTER: Lizano PL 

PROVIDER: S-EPMC5432401 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature