Oxytocin Acts in Nucleus Accumbens to Attenuate Methamphetamine Seeking and Demand.

ABSTRACT:

Background

Evidence indicates that oxytocin, an endogenous peptide well known for its role in social behaviors, childbirth, and lactation, is a promising addiction pharmacotherapy. We employed a within-session behavioral-economic (BE) procedure in rats to examine oxytocin as a pharmacotherapy for methamphetamine (meth) addiction. The BE paradigm was modeled after BE procedures used to assess motivation for drugs in humans with addiction. The same BE variables assessed across species have been shown to predict later relapse behavior. Thus, the translational potential of preclinical BE studies is particularly strong.

Methods

We tested the effects of systemic and microinfused oxytocin on demand for self-administered intravenous meth and reinstatement of extinguished meth seekin

SUBMITTER: Cox BM 

PROVIDER: S-EPMC5432412 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature