Genetic Comparison of Symptomatic and Asymptomatic Persons With Alzheimer Disease Neuropathology.

ABSTRACT:

Objective

The objective was to determine whether symptomatic and asymptomatic persons with Alzheimer disease (AD) neuropathology have different allele counts for single-nucleotide polymorphisms that have been associated with clinical late-onset AD.

Methods

Data came from the National Alzheimer's Coordinating Center Uniform Data Set and Neuropathology Data Set, and the Alzheimer's Disease Genetics Consortium (ADGC). Participants had low to high AD neuropathologic change. The 22 known/suspected genes associated with late-onset AD were considered. "Symptomatic" was defined as Clinical Dementia Rating global score >0.

Results

Sixty-eight asymptomatic and 521 symptomatic participants met inclusion criteria. Single-nucleotide polymorphisms associated with ABCA7 [odds ratio

SUBMITTER: Monsell SE 

PROVIDER: S-EPMC5432419 | biostudies-literature | 2017 Jul-Sep

REPOSITORIES: biostudies-literature