Association between functional antibody against Group B Streptococcus and maternal and infant colonization in a Gambian cohort.

ABSTRACT:

Background

Vertical transmission of Group B Streptococcus (GBS) is a prerequisite for early-onset disease and a consequence of maternal GBS colonization. Disease protection is associated with maternally-derived anti-GBS antibody. Using a novel antibody-mediated C3b/iC3b deposition flow cytometry assay which correlates with opsonic killing we developed a model to assess the impact of maternally-derived functional anti-GBS antibody on infant GBS colonization from birth to day 60-89 of life.

Methods

Rectovaginal swabs and cord blood (birth) and infant nasopharyngeal/rectal swabs (birth, day 6 and day 60-89) were obtained from 750 mother/infant pairs. Antibody-mediated C3b/iC3b deposition with cord and infant sera was measured by flow cytometry.

Results

We established tha

SUBMITTER: Le Doare K 

PROVIDER: S-EPMC5432431 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature