Metabolic imaging of energy metabolism in traumatic brain injury using hyperpolarized [1-¹³C]pyruvate.

ABSTRACT: Traumatic brain injury (TBI) is known to cause perturbations in the energy metabolism of the brain, but current tests of metabolic activity are only indirect markers of energy use or are highly invasive. Here we show that hyperpolarized ¹³C magnetic resonance spectroscopic imaging (MRSI) can be used as a direct, non-invasive method for studying the effects of TBI on energy metabolism. Measurements were performed on rats with moderate TBI induced by controlled cortical impact on one cerebral hemisphere. Following injection of hyperpolarized [1-¹³C]pyruvate, the resulting ¹³C-bicarbonate signal was found to be 24 ± 6% lower in the injured hemisphere compared with the non-injured hemisphere, while the hyperpolarized bicarbonate-to-lactate ratio was 33 ± 8% low

SUBMITTER: DeVience SJ 

PROVIDER: S-EPMC5432492 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature