Deletion of Slc26a1 and Slc26a7 Delays Enamel Mineralization in Mice.

ABSTRACT: Amelogenesis features two major developmental stages-secretory and maturation. During maturation stage, hydroxyapatite deposition and matrix turnover require delicate pH regulatory mechanisms mediated by multiple ion transporters. Several members of the Slc26 gene family (Slc26a1, Slc26a3, Slc26a4, Slc26a6, and Slc26a7), which exhibit bicarbonate transport activities, have been suggested by previous studies to be involved in maturation-stage amelogenesis, especially the key process of pH regulation. However, details regarding the functional role of these genes in enamel formation are yet to be clarified, as none of the separate mutant animal lines demonstrates any discernible enamel defects. Continuing with our previous investigation of Slc26a1^-/- and Slc26a7

SUBMITTER: Yin K 

PROVIDER: S-EPMC5432648 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature