Further Characterization of the Bifunctional HIV Entry Inhibitor sCD4-FI_T45.

ABSTRACT: HIV entry into target cells is a highly sequential and time-sensitive process. In recent years, potent HIV Env-targeting antibodies, such as VRC01, have been identified. However, antibodies bind only to a single epitope, and mutations that confer resistance to antibody-mediated inhibition of HIV entry have been detected. In contrast, HIV cannot escape from binding to soluble CD4 (sCD4) without a fitness disadvantage. sCD4 has the unique ability to induce conformational changes within the HIV envelope glycoproteins (Env) that allow fusion inhibitors to bind. We have previously linked sCD4 to the fusion inhibitor FI_T45 (sCD4-FI_T45) and examined delivery of the bifunctional entry inhibitor via gene therapy. Here, we extend our studies and analyze the ability of sCD4-FI

SUBMITTER: Falkenhagen A 

PROVIDER: S-EPMC5432676 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature