Association between left ventricular function and paraprotein type in patients with multiple myeloma.

ABSTRACT:

Background/aims

Multiple myeloma (MM)-associated cardiac damage, particularly according to the type of monoclonal (M) protein has not been elucidated. We sought to investigate relationship between elevated serum M protein levels and echocardiographic indices of cardiac structure and function in patients with MM.

Methods

We evaluated a total of 184 consecutive MM patients who underwent echocardiography for bone marrow pre-transplant screening. Serum levels of intact immunoglobulin M protein and free light chain kappa/lambda (FLC-κ/-λ) were measured.

Results

One hundred thirty-nine patients were non-light chain MM (non-LCMM) and 45 patients belonged to LCMM. In patients with non-LCMM, significant correlations were found between serum M protein and left atrial volume ind

SUBMITTER: Yi JE 

PROVIDER: S-EPMC5432795 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature