Epigenome-wide association of myocardial infarction with DNA methylation sites at loci related to cardiovascular disease.

ABSTRACT:

Background

Development of cardiovascular disease (CVD), including coronary artery disease, arrhythmia, and ischemic stroke, depends on environmental and genetic factors. To investigate the epigenetic basis of myocardial infarction (MI), we performed an epigenome-wide association study for this condition in elderly Japanese subjects. A total of 192 case subjects with MI and 192 control subjects were recruited from hospital attendees and the general population, respectively. Genome-wide DNA methylation (DNAm) profiles for DNA isolated from whole blood were obtained by analysis with an Infinium HumanMethylation450 BeadChip. The relation of DNAm sites found to be significantly associated with MI to nearby single nucleotide polymorphisms (SNPs) previously shown to be associated with CVD

SUBMITTER: Nakatochi M 

PROVIDER: S-EPMC5432989 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature