An organometallic structure-activity relationship study reveals the essential role of a Re(CO)₃ moiety in the activity against gram-positive pathogens including MRSA.

ABSTRACT: The worrying appearance of microbial resistance to antibiotics is a worldwide problem which needs to be tackled urgently. Microbial resistance to the common classes of antibiotics involving purely organic compounds unfortunately develops very rapidly and in most cases, resistance was detected soon after or even before release of the antibiotic to the market. Therefore, novel concepts for antibiotics must be investigated, and metal-containing compounds hold particular promise in that area. Taking a trimetallic complex (1a) which contains a ferrocenyl (Fc), a CpMn(CO)₃ (cymantrene) and a [(dpa)Re(CO)₃] residue as the lead structure, a systematic structure-activity relationship (SAR) study against various gram-positive pathogenic bacteria including methicillin-res

SUBMITTER: Patra M 

PROVIDER: S-EPMC5433042 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature