Changes in microbial ecology after fecal microbiota transplantation for recurrent C. difficile infection affected by underlying inflammatory bowel disease.

ABSTRACT:

Background

Gut microbiota play a key role in maintaining homeostasis in the human gut. Alterations in the gut microbial ecosystem predispose to Clostridium difficile infection (CDI) and gut inflammatory disorders such as inflammatory bowel disease (IBD). Fecal microbiota transplantation (FMT) from a healthy donor can restore gut microbial diversity and pathogen colonization resistance; consequently, it is now being investigated for its ability to improve inflammatory gut conditions such as IBD. In this study, we investigated changes in gut microbiota following FMT in 38 patients with CDI with or without underlying IBD.

Results

There was a significant change in gut microbial composition towards the donor microbiota and an overall increase in microbial diversity consistent wit

SUBMITTER: Khanna S 

PROVIDER: S-EPMC5433077 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature