Rp58 and p27^kip1 coordinate cell cycle exit and neuronal migration within the embryonic mouse cerebral cortex.

ABSTRACT:

Background

During the development of the mammalian cerebral cortex, newborn postmitotic projection neurons are born from local neural stem cells and must undergo radial migration so as to position themselves appropriately to form functional neural circuits. The zinc finger transcriptional repressor Rp58 (also known as Znf238 or Zbtb18) is critical for coordinating corticogenesis, but its underlying molecular mechanism remains to be better characterised.

Findings

Here, we demonstrate that the co-expression of Rp58 and the cyclin dependent kinase inhibitor (CDKI) p27^kip1 is important for E14.5-born cortical neurons to coordinate cell cycle exit and initiate their radial migration. Notably, we find that the impaired radial positioning of Rp58-deficient cortical neuro

SUBMITTER: Clement O 

PROVIDER: S-EPMC5433244 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature