Metreleptin therapy lowers plasma angiopoietin-like protein 3 in patients with generalized lipodystrophy.

ABSTRACT:

Background

Reduced triglyceride clearance due to impaired lipoprotein lipase-mediated lipolysis contributes to severe hypertriglyceridemia in lipodystrophy. Angiopoietin-like protein 3 (ANGPTL3) and 4 (ANGPTL4) impair clearance of triglycerides by inhibiting lipoprotein lipase. Whether circulating ANGPTL3/4 levels are altered in lipodystrophy and the effects of leptin replacement on these ANGPTLs are unknown.

Objective

To examine if ANGPTL3/4 levels are elevated in patients with generalized lipodystrophy and assess the effects of leptin replacement on these ANGPTLs.

Methods

Preleptin treatment plasma levels of ANGPTLs in patients with generalized lipodystrophy (n = 22) were compared with healthy controls (n = 39) using a post hoc case-control study design. In a prospe

SUBMITTER: Muniyappa R 

PROVIDER: S-EPMC5433252 | biostudies-literature | 2017 Mar - Apr

REPOSITORIES: biostudies-literature