Correlation of Crtc1/3-Maml2 fusion status, grade and survival in mucoepidermoid carcinoma.

ABSTRACT:

Objective

Mucoepidermoid carcinoma (MEC) is the most common malignant tumor of the salivary glands. Tumor stage and grade have historically been important predictors of survival. An oncogenic CRTC1- or CRTC3-MAML2 gene fusion has been identified in a number of MECs. Historically, these gene fusions have been associated with lower grade tumors and better survival. However, reported gene fusion rates and prognosis varies widely across studies, and have not controlled for tumor grade. We sought to identify gene fusion rates and outcomes in our cohort of MEC patients.

Materials and methods

An IRB-approved retrospective cohort of patients with MEC was identified at the University of Michigan. Clinical, histologic, and outcome data was collected from medical records. RNA was isola

SUBMITTER: Birkeland AC 

PROVIDER: S-EPMC5433350 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature