Genome-wide associations of CD46 and IFI44L genetic variants with neutralizing antibody response to measles vaccine.

ABSTRACT: Population-based studies have revealed 2-10% measles vaccine failure rate even after two vaccine doses. While the mechanisms behind this remain unknown, we hypothesized that host genetic factors are likely to be involved. We performed a genome-wide association study of measles specific neutralizing antibody and IFNγ ELISPOT response in a combined sample of 2872 subjects. We identified two distinct chromosome 1 regions (previously associated with MMR-related febrile seizures), associated with vaccine-induced measles neutralizing antibody titers. The 1q32 region contained 20 significant SNPs in/around the measles virus receptor-encoding CD46 gene, including the intronic rs2724384 (p value = 2.64 × 10^-09) and rs2724374 (p value = 3.16 × 10^-09) SNPs. The 1q31.1 region con

SUBMITTER: Haralambieva IH 

PROVIDER: S-EPMC5433429 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature