Assessment of Clinical Criteria for Sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).

ABSTRACT:

Importance

The Third International Consensus Definitions Task Force defined sepsis as "life-threatening organ dysfunction due to a dysregulated host response to infection." The performance of clinical criteria for this sepsis definition is unknown.

Objective

To evaluate the validity of clinical criteria to identify patients with suspected infection who are at risk of sepsis.

Design, settings, and population

Among 1.3 million electronic health record encounters from January 1, 2010, to December 31, 2012, at 12 hospitals in southwestern Pennsylvania, we identified those with suspected infection in whom to compare criteria. Confirmatory analyses were performed in 4 data sets of 706,399 out-of-hospital and hospital encounters at 165 US and non-US hospitals ranging from Ja

SUBMITTER: Seymour CW 

PROVIDER: S-EPMC5433435 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature