Burden of genetic risk variants in multiple sclerosis families in the Netherlands.

ABSTRACT:

Background

Approximately 20% of multiple sclerosis patients have a family history of multiple sclerosis. Studies of multiple sclerosis aggregation in families are inconclusive.

Objective

To investigate the genetic burden based on currently discovered genetic variants for multiple sclerosis risk in patients from Dutch multiple sclerosis multiplex families versus sporadic multiple sclerosis cases, and to study its influence on clinical phenotype and disease prediction.

Methods

Our study population consisted of 283 sporadic multiple sclerosis cases, 169 probands from multiplex families and 2028 controls. A weighted genetic risk score based on 102 non-human leukocyte antigen loci and HLA-DRB1*1501 was calculated.

Results

The weighted genetic risk score based

SUBMITTER: Mescheriakova JY 

PROVIDER: S-EPMC5433503 | biostudies-literature | 2016 Jan-Dec

REPOSITORIES: biostudies-literature