SPR-based fragment screening with neurotensin receptor 1 generates novel small molecule ligands.

ABSTRACT: The neurotensin receptor 1 represents an important drug target involved in various diseases of the central nervous system. So far, the full exploitation of potential therapeutic activities has been compromised by the lack of compounds with favorable physicochemical and pharmacokinetic properties which efficiently penetrate the blood-brain barrier. Recent progress in the generation of stabilized variants of solubilized neurotensin receptor 1 and its subsequent purification and successful structure determination presents a solid starting point to apply the approach of fragment-based screening to extend the chemical space of known neurotensin receptor 1 ligands. In this report, surface plasmon resonance was used as primary method to screen 6369 compounds. Thereby 44 hits were identified and c

SUBMITTER: Huber S 

PROVIDER: S-EPMC5433701 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature