Dataset Information

Association of Testosterone Levels With Anemia in Older Men: A Controlled Clinical Trial.

ABSTRACT:

Importance

In one-third of older men with anemia, no recognized cause can be found.

Objective

To determine if testosterone treatment of men 65 years or older with unequivocally low testosterone levels and unexplained anemia would increase their hemoglobin concentration.

Design, setting, and participants

A double-blinded, placebo-controlled trial with treatment allocation by minimization using 788 men 65 years or older who have average testosterone levels of less than 275 ng/dL. Of 788 participants, 126 were anemic (hemoglobin ≤12.7 g/dL), 62 of whom had no known cause. The trial was conducted in 12 academic medical centers in the United States from June 2010 to June 2014.