Chemical composition and phagocyte immunomodulatory activity of Ferula iliensis essential oils.

ABSTRACT: Essential oil extracts from Ferula iliensis have been used traditionally in Kazakhstan for treatment of inflammation and other illnesses. Because little is known about the biologic activity of these essential oils that contributes to their therapeutic properties, we analyzed their chemical composition and evaluated their phagocyte immunomodulatory activity. The main components of the extracted essential oils were (E)-propenyl sec-butyl disulfide (15.7-39.4%) and (Z)-propenyl sec-butyl disulfide (23.4-45.0%). Ferula essential oils stimulated [Ca²⁺]_i mobilization in human neutrophils and activated ROS production in human neutrophils and murine bone marrow phagocytes. Activation of human neutrophil [Ca²⁺]_i f

SUBMITTER: Ozek G 

PROVIDER: S-EPMC5433855 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature