Domoic acid disrupts the activity and connectivity of neuronal networks in organotypic brain slice cultures.

ABSTRACT: Domoic acid is a neurotoxin produced by algae and is found in seafood during harmful algal blooms. As a glutamate agonist, domoic acid inappropriately stimulates excitatory activity in neurons. At high doses, this leads to seizures and brain lesions, but it is unclear how lower, asymptomatic exposures disrupt neuronal activity. Domoic acid has been detected in an increasing variety of species across a greater geographical range than ever before, making it critical to understand the potential health impacts of low-level exposure on vulnerable marine mammal and human populations. To determine whether prolonged domoic acid exposure altered neuronal activity in hippocampal networks, we used a custom-made 512 multi-electrode array with high spatial and temporal resolution to record extracellula

SUBMITTER: Hiolski EM 

PROVIDER: S-EPMC5433861 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature