Structure Based docking studies towards exploring potential anti-androgen activity of selected phytochemicals against Prostate Cancer.

ABSTRACT: Prostate cancer (PCa) is the second most common malignancy amongst men worldwide. Under PCa maintenance therapy drugs acting as antagonists/partial agonists of hormone receptors against the prostate tissue are used in clinical practices. Prominent drugs being Cyproterone acetate, Flutamide, Bicalutamide, they not only cause acute and long-term toxicity, but also develops drug resistance among patients. Our focus has been on phytochemicals which do not exhibit any cytotoxicity and have significant androgen receptor (AR) inhibition activity. As Protein- Ligand interactions play a key role in structure based drug design, so by using molecular docking, we screened 803 phytochemicals and investigated their binding affinity against AR. The three dimensional (3D) structure of AR was retrieved fro

SUBMITTER: Singh AN 

PROVIDER: S-EPMC5434041 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature