A new paradigm in sweat based wearable diagnostics biosensors using Room Temperature Ionic Liquids (RTILs).

ABSTRACT: Successful commercialization of wearable diagnostic sensors necessitates stability in detection of analytes over prolonged and continuous exposure to sweat. Challenges are primarily in ensuring target disease specific small analytes (i.e. metabolites, proteins, etc.) stability in complex sweat buffer with varying pH levels and composition over time. We present a facile approach to address these challenges using RTILs with antibody functionalized sensors on nanoporous, flexible polymer membranes. Temporal studies were performed using both infrared spectroscopic, dynamic light scattering, and impedimetric spectroscopy to demonstrate stability in detection of analytes, Interleukin-6 (IL-6) and Cortisol, from human sweat in RTILs. Temporal stability in sensor performance was performed as follo

SUBMITTER: Munje RD 

PROVIDER: S-EPMC5434046 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature