Lactic acid bacteria-specific induction of CD4⁺Foxp3⁺T cells ameliorates shrimp tropomyosin-induced allergic response in mice via suppression of mTOR signaling.

ABSTRACT: The beneficial effects of probiotics have been described in allergic sensitization and diseases; however, many questions remain unanswered, such as characteristics of the most effective strains in modulation of allergic responses and how orally administered probiotics affect the systemic immune system. In the present work, oral administration of five lactic acid bacteria strains showed variable effects on protection against the allergic reaction in a mouse model of food allergy to shrimp tropomyosin (ST). The most effective anti-allergic strain, Bacillus coagulans 09.712 (Bc), greatly improved epithelial barrier function and increased lymphocytes proliferation. Moreover, Bc suppresses ST sensitization by altering Th1/Th2/Treg balance as a result of strong induction of CD4⁺Foxp3<

SUBMITTER: Fu L 

PROVIDER: S-EPMC5434066 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature