Computational design of treatment strategies for proactive therapy on atopic dermatitis using optimal control theory.

ABSTRACT: Atopic dermatitis (AD) is a common chronic skin disease characterized by recurrent skin inflammation and a weak skin barrier, and is known to be a precursor to other allergic diseases such as asthma. AD affects up to 25% of children worldwide and the incidence continues to rise. There is still uncertainty about the optimal treatment strategy in terms of choice of treatment, potency, duration and frequency. This study aims to develop a computational method to design optimal treatment strategies for the clinically recommended 'proactive therapy' for AD. Proactive therapy aims to prevent recurrent flares once the disease has been brought under initial control. Typically, this is done by using an anti-inflammatory treatment such as a potent topical corticosteroid intensively for a few weeks to

SUBMITTER: Christodoulides P 

PROVIDER: S-EPMC5434076 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature