Lateral Entorhinal Cortex Lesions Impair Local Spatial Frameworks.

ABSTRACT: A prominent theory in the neurobiology of memory processing is that episodic memory is supported by contextually gated spatial representations in the hippocampus formed by combining spatial information from medial entorhinal cortex (MEC) with non-spatial information from lateral entorhinal cortex (LEC). However, there is a growing body of evidence from lesion and single-unit recording studies in rodents suggesting that LEC might have a role in encoding space, particularly the current and previous locations of objects within the local environment. Landmarks, both local and global, have been shown to control the spatial representations hypothesized to underlie cognitive maps. Consequently, it has recently been suggested that information processing within this network might be organized with

SUBMITTER: Kuruvilla MV 

PROVIDER: S-EPMC5434111 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature