Olfaction in Parkin carriers in Chinese patients with Parkinson disease.

ABSTRACT:

Background

Olfactory identification was reported to be better among PD (Parkinson disease) patients with Parkin mutations, but previous studies didn't eliminate the interference of other PD related genes on olfaction, and whether olfaction of Parkin mutations patients was better in Chinese population was still unknown.

Objective

To assess olfaction function among PD patients with Parkin mutations in Chinese population.

Materials and methods

A total of 226 PD patients with a positive family history or an early-onset age (<50 years) were enrolled for genetic testing of PD related genes by target sequencing and multiple ligation-dependent probe amplification. The clinical data including olfactory function test were investigated. Linear regression was

SUBMITTER: Wang Y 

PROVIDER: S-EPMC5434185 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature