Interpersonal early-life trauma alters amygdala connectivity and sustained attention performance.

ABSTRACT:

Introduction

Interpersonal early life trauma (I-ELT) is associated with a myriad of functional impairments in adulthood, increased risk of drug addiction, and neuropsychiatric disorders. While deficits in emotional regulation and amygdala functioning are well characterized, deficits in general cognitive functioning have also been documented. However, the neural underpinnings of cognitive dysfunction in adults with a history of I-ELT and the potential relationship between amygdala-based functional connectivity and behavioral performance are currently poorly understood. This study examined how I-ELT affects the cognitive and neural mechanisms supporting sustained attention.

Methods

A total of 66 Veterans (18 with and 48 without a history of I-ELT) completed a nonemotional sust

SUBMITTER: Fortenbaugh FC 

PROVIDER: S-EPMC5434189 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature