The effect of COMT Val158Met and DRD2 C957T polymorphisms on executive function and the impact of early life stress.

ABSTRACT:

Introduction

Previous research has indicated that variation in genes encoding catechol-O-methyltransferase (COMT) and dopamine receptor D2 (DRD2) may influence cognitive function and that this may confer vulnerability to the development of mental health disorders such as schizophrenia. However, increasing evidence suggests environmental factors such as early life stress may interact with genetic variants in affecting these cognitive outcomes. This study investigated the effect of COMT Val158Met and DRD2 C957T polymorphisms on executive function and the impact of early life stress in healthy adults.

Methods

One hundred and twenty-two healthy adult males (mean age 35.2 years, range 21-63) were enrolled in the study. Cognitive function was assessed u

SUBMITTER: Klaus K 

PROVIDER: S-EPMC5434197 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature