Practice Patterns and Outcomes Associated With Procalcitonin Use in Critically Ill Patients With Sepsis.

ABSTRACT:

Background.

Randomized trials support use of procalcitonin (PCT)-based algorithms to decrease duration of antibiotics for critically ill patients with sepsis. However, current use of PCT and associated outcomes in real-world clinical settings is unclear. We sought to determine PCT use in critically ill patients with sepsis in the United States and to examine associations between PCT use and clinical outcomes.

Methods.

This was a retrospective cohort study of approximately 20% of patients with sepsis hospitalized in US intensive care units. Hierarchical regression models were used to determine associations of PCT use with outcomes (antibiotic-days, incidence of Clostridium difficile infection, and in-hospital mortality). Sensitivity analyses were conducted to assess robustnes

SUBMITTER: Chu DC 

PROVIDER: S-EPMC5434362 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature