Investigating the Genetic Architecture of the PR Interval Using Clinical Phenotypes.

ABSTRACT:

Background

One potential use for the PR interval is as a biomarker of disease risk. We hypothesized that quantifying the shared genetic architectures of the PR interval and a set of clinical phenotypes would identify genetic mechanisms contributing to PR variability and identify diseases associated with a genetic predictor of PR variability.

Methods and results

We used ECG measurements from the ARIC study (Atherosclerosis Risk in Communities; n=6731 subjects) and 63 genetically modulated diseases from the eMERGE network (Electronic Medical Records and Genomics; n=12 978). We measured pairwise genetic correlations (rG) between PR phenotypes (PR interval, PR segment, P-wave duration) and each of the 63 phenotypes. The PR segment was genetically correlated with atrial fibrillat

SUBMITTER: Mosley JD 

PROVIDER: S-EPMC5434456 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature