Dataset Information

Cytotoxicity of Pyrazine-Based Cyclometalated (C^N^pz^C)Au(III) Carbene Complexes: Impact of the Nature of the Ancillary Ligand on the Biological Properties.

ABSTRACT: The synthesis of a series of cyclometalated gold(III) complexes supported by pyrazine-based (C^N^C)-type pincer ligands is reported, including the crystal structure of a cationic example. The compounds provide a new platform for the study of antiproliferative properties of gold(III) complexes. Seven complexes were tested: the neutral series (C^N^pz^C)AuX [X = Cl (1), 6-thioguanine (4), C≡CPh (5), SPh (6)] and an ionic series that included the N-methyl complex [(C^N^pzMe^C)AuCl]BF₄ (7) and the N-heterocyclic carbene complexes [(C^N^pz^C)AuL]⁺ with L = 1,3-dimethylbenzimidazol-2-ylidene (2) or 1,3,7,9-tetramethylxanthin-8-ylidene (3). Tests against human leukemia cells identified 1, 2, 3, and 4 as particularly promising, whereas protecting

SUBMITTER: Bertrand B

PROVIDER: S-EPMC5434479 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Dataset Information

Cytotoxicity of Pyrazine-Based Cyclometalated (C^N^pz^C)Au(III) Carbene Complexes: Impact of the Nature of the Ancillary Ligand on the Biological Properties.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Cytotoxicity of Pyrazine-Based Cyclometalated (C^Npz^C)Au(III) Carbene Complexes: Impact of the Nature of the Ancillary Ligand on the Biological Properties.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Cytotoxicity of Pyrazine-Based Cyclometalated (C^N^pz^C)Au(III) Carbene Complexes: Impact of the Nature of the Ancillary Ligand on the Biological Properties.