External validation of the ProCaRS nomograms and comparison of existing risk-stratification tools for localized prostate cancer.

ABSTRACT: INTRODUCTION:The purpose of this study was to perform a direct comparison of several existing risk-stratification tools for localized prostate cancer in terms of their ability to predict for biochemical failure-free survival (BFFS). Two large databases were used and an external validation of two recently developed nomograms on an independent cohort was also performed in this analysis. METHODS:Patients who were treated with external beam radiotherapy (EBRT) and/or brachytherapy for localized prostate cancer were selected from the multi-institutional Genitourinary Radiation Oncologists of Canada (GUROC) Prostate Cancer Risk Stratification (ProCaRS) database (n=7974) and the Centre Hospitalier de l'Université de Montréal (CHUM) validation database (n=2266). The primary outcome was BFFS using

SUBMITTER: Tiberi D 

PROVIDER: S-EPMC5434512 | biostudies-literature | 2017 Mar-Apr

REPOSITORIES: biostudies-literature