Polymeric micelles with dual thermal and reactive oxygen species (ROS)-responsiveness for inflammatory cancer cell delivery.

ABSTRACT:

Background

The object of this study was to develop a thermally and reactive oxygen species-responsive nanocarrier system for cancer therapy.

Results

PPS-PNIPAm block copolymer was designed and synthesised using a combination of living anionic ring-opening polymerization and atom transfer radical polymerization. The synthesized polymer formed micellar aggregates in water and demonstrated dual responsiveness towards temperature and oxidants. Using doxorubicin (DOX) as a model drug, encapsulation and in vitro release of the drug molecules in PPS-PNIPAm nanocarriers confirmed the responsive release properties of such system. Cell uptake of the DOX loaded micelles was investigated with human breast cancer cell line (MCF-7). The results showed Dox-loaded micelles were able to be t

SUBMITTER: Tang M 

PROVIDER: S-EPMC5434630 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature