Structural and functional brain network correlates of depressive symptoms in premanifest Huntington's disease.

ABSTRACT: Depression is common in premanifest Huntington's disease (preHD) and results in significant morbidity. We sought to examine how variations in structural and functional brain networks relate to depressive symptoms in premanifest HD and healthy controls. Brain networks were constructed using diffusion tractography (70 preHD and 81 controls) and resting state fMRI (92 preHD and 94 controls) data. A sub-network associated with depression was identified in a data-driven fashion and network-based statistics was used to investigate which specific connections correlated with depression scores. A replication analysis was then performed using data from a separate study. Correlations between depressive symptoms with increased functional connectivity and decreased structural connectivity were seen for

SUBMITTER: McColgan P 

PROVIDER: S-EPMC5434856 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature