Humanized mouse model for assessing the human immune response to xenogeneic and allogeneic decellularized biomaterials.

ABSTRACT: Current assessment of biomaterial biocompatibility is typically implemented in wild type rodent models. Unfortunately, different characteristics of the immune systems in rodents versus humans limit the capability of these models to mimic the human immune response to naturally derived biomaterials. Here we investigated the utility of humanized mice as an improved model for testing naturally derived biomaterials. Two injectable hydrogels derived from decellularized porcine or human cadaveric myocardium were compared. Three days and one week after subcutaneous injection, the hydrogels were analyzed for early and mid-phase immune responses, respectively. Immune cells in the humanized mouse model, particularly T-helper cells, responded distinctly between the xenogeneic and allogeneic biomateria

SUBMITTER: Wang RM 

PROVIDER: S-EPMC5434867 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature