Animal models of maternal high fat diet exposure and effects on metabolism in offspring: a meta-regression analysis.

ABSTRACT: Animal models of maternal high fat diet (HFD) demonstrate perturbed offspring metabolism although the effects differ markedly between models. We assessed studies investigating metabolic parameters in the offspring of HFD fed mothers to identify factors explaining these inter-study differences. A total of 171 papers were identified, which provided data from 6047 offspring. Data were extracted regarding body weight, adiposity, glucose homeostasis and lipidaemia. Information regarding the macronutrient content of diet, species, time point of exposure and gestational weight gain were collected and utilized in meta-regression models to explore predictive factors. Publication bias was assessed using Egger's regression test. Maternal HFD exposure did not affect offspring birthweight but increased

SUBMITTER: Ribaroff GA 

PROVIDER: S-EPMC5434919 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature