Evidence for a Strong Correlation Between Transcription Factor Protein Disorder and Organismic Complexity.

ABSTRACT: Studies of diverse phylogenetic lineages reveal that protein disorder increases in concert with organismic complexity but that differences nevertheless exist among lineages. To gain insight into this phenomenology, we analyzed all of the transcription factor (TF) families for which sequences are known for 17 species spanning bacteria, yeast, algae, land plants, and animals and for which the number of different cell types has been reported in the primary literature. Although the fraction of disordered residues in TF sequences is often moderately or poorly correlated with organismic complexity as gauged by cell-type number (r2 < 0.5), an unbiased and phylogenetically broad analysis shows that organismic complexity is positively and strongly correlated with the total number of TFs, the number

SUBMITTER: Yruela I 

PROVIDER: S-EPMC5434936 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature