Hepatic and Plasma Endothelin-1 in Dogs with Chronic Hepatitis.

ABSTRACT:

Background

Endothelin (ET)-1 is a 21-amino-acid peptide with potent vasoactive properties, which increases intrahepatic resistance in patients with chronic hepatitis (CH) or cirrhosis. ET-1 concentrations have not been investigated in dogs with CH.

Hypothesis/objectives

This study compared hepatic and plasma ET-1 levels in healthy dogs and in dogs with CH, and examined the relationship between the plasma ET-1 level and portal vein pressure in dogs with CH.

Animals

Fourteen healthy dogs and twenty dogs with CH were used in this study.

Methods

Prospective case-control study. Hepatic ET-1 mRNA expression was determined by real-time reverse transcription polymerase chain reaction, and hepatic and plasma ET-1 levels were assessed using ELISA. Splenic pulp pressure (

SUBMITTER: Sakamoto Y 

PROVIDER: S-EPMC5435058 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature