Biological Variability in Serum Cortisol Concentration Post-adrenocorticotropic Hormone Stimulation in Healthy Dogs.

ABSTRACT:

Background

The ACTH stimulation has low sensitivity for the diagnosis of hypercortisolism possibly as a result of biological and analytical variability.

Hypothesis/objectives

To report the components of biological and analytical variability in serum cortisol concentration post-ACTH stimulation ([cortisol]) in healthy dogs.

Animals

Fourteen healthy harrier hound dogs.

Methods

The data were extracted from a separate, prospective, randomized, double-blinded, controlled discovery study in which dogs treated with vehicle control and 4 different doses of cortisone acetate (CA) for 7 days had an ACTH stimulation test performed to confirm the dose-dependent effect of CA. The index of individuality (IoI), the critical difference between sequential measurements (C_D<

SUBMITTER: Gal A 

PROVIDER: S-EPMC5435067 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature